2009
Martha, C.T.; Heemskerk, A.; Hoogendoorn, J.C.; Elders, N.; Niessen, W.M.A.; Orru, R.V.A.; Irth, H. “High-Throughput Reaction Optimisation and Activity Screening of Ferrocene-Based Lewis Acid-Catalyst Complexes by Using Continuous-Flow Reaction Detection Mass Spectrometry” Chem. Eur J. 2009, 15, 7368-7375.
Elders, N.; van der Born, D.; Hendrickx, L. J. D. ; Timmer, B. J. J.; Krause, A.; Janssen, E.; de Kanter, F. J. J.; Ruijter, E.; Orru, R. V. A. “The Efficient One-Pot Reaction of up to Eight Components by the Union of Multicomponent Reactions” Angew. Chem. Int. Ed. 2009, 48, 5856-5859.
Elders, N.; Ruijter, E.; de Kanter, F. J. J.; Janssen, E.; Lutz, M.; Spek, A. L.; Orru, R. V. A. “A Multicomponent Reaction Towards N-(Cyanomethyl)amides” Chem. Eur. J. 2009, 15, 6096-6099.
Scheffelaar, R.; Klein Nijenhuis, R.A.; Paravidino, M.; Lutz, M.; Spek, A.L.; Ehlers, A.W.; de Kanter, F.J.J.; Groen, M.B. Orru, R.V.A.; Ruijter, E. “Synthesis of Conformationally Constrained Peptidomimetics using Multicomponent Reactions” J. Org. Chem. 2009, 74, 660-668.
Scheffelaar, R.; Paravidino, M.; Muilwijk, D.; Lutz, M.; Spek, A.L.; de Kanter, F.J.J.; Orru, R.V.A.; Ruijter, E. “A Novel Three-Component Reaction toward Dihydrooxazolopyridines” Org. Lett. 2009,11, 125-128.
Gubbens, J.; Ruijter, E.; de Fays, L.E.V.; Damen, J.M.A.; de Kruijff, B.; Slijper, M.; Rijkers, D.T.S.; Liskamp, R.M.J.; de Kroon, A.I.P.M. “Photocrosslinking and Click Chemistry Enable the Specific Detection of Proteins Interacting with Phospholipids at the Membrane Interface” Chem. Biol. 2009, 16, 3-14.
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2008
Groenendaal, B.; Ruijter, E.; Orru, R.V.A. “1-Azadienes in Cycloaddition and Multicomponent Reactions towards N-heterocycles” Chem. Commun. 2008, 5474-5489 (feature article).
Martha, C.T.; Elders, N.; Krabbe, J.G.; Kool, J.; Niessen, W.M.A.; Orru, R.V.A.; Irth, H. “Online Screening of Homogeneous Catalyst Performance Using Reaction Detection Mass Spectrometry” Anal. Chem. 2008, 80, 7121-7127.
Groenendaal, B.; Ruijter, E.; de Kanter, F.J.J.; Lutz, M.; Spek, A.L.; Orru, R.V.A. “Generation of Molecular Diversity Using a Complexity-Generating MCR-Platform towards Triazinane Diones” Org. Biomol. Chem. 2008, 6, 3158-3165.
Elders, N.; Ruijter, E.; de Kanter, F.J.J.; Groen, M.B.; Orru, R.V.A. “Selective Formation of 2-Imidazolines and 2-Substituted Oxazoles by Using a Three-Component Reaction” Chem. Eur. J. 2008, 14, 4961-4973.
Vugts, D.J.; Aktas, H.; Al-Mafraji, K.; de Kanter, F.J.J.; Ruijter, E.; Groen, M.B.; Orru, R.V.A. “Synthesis of 3′-Deoxyribolactones using a Hydrolysis-Induced Lactonization Cascade Reaction of Epoxy Cyanohydrins” Eur. J. Org. Chem. 2008, 1336-1339.
Groenendaal, B.; Vugts, D.J.; Schmitz, R.F.; de Kanter, F.J.J.; Ruijter, E.; Groen, M.B.; Orru, R.V.A. “A Multicomponent Synthesis of Triazinane Diones” J. Org. Chem. 2008, 73, 719-722.
Bon, R.S.; Sprenkels, N.E.; Koningstein, M.M.; Schmitz, R.F.; de Kanter, F.J.J.; Dömling, A.; Groen, M.B.; Orru, R.V.A. “Efficient C2 Functionalisation of 2H-2-Imidazolines” Org. Biomol. Chem. 2008, 6, 130-137.
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2007
Paravidino, M.; Scheffelaar, R.; Schmitz, R.F.; de Kanter, F.J.J.; Groen, M.B.; Ruijter, E.; Orru, R.V.A. “A Flexible Six-Component Reaction to Access Constrained Depsipeptides Based on a Dihydropyridinone Core.” J. Org. Chem. 2007, 72, 10239-10242.
Elders, N.; Schmitz, R.F.; de Kanter, F.J.J.; Ruijter, E.; Groen, M.B.; Orru, R.V.A. “A Resource-Efficient and Highly Flexible Procedure for a Three-Component Synthesis of 2-Imidazolines” J. Org. Chem. 2007, 72, 6135-6142.
Bon, R.S.; de Kanter, F.J.J.; Lutz, M.; Spek, A.L.; Jahnke, M.C.; Hahn, F.E.; Groen, M.B.; Orru, R.V.A. “Multicomponent Synthesis of N-heterocyclic Carbene Complexes” Organometallics 2007, 26, 3639-3650.
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2006
de Greef, M.; Abeln, S.; Belkasmi, K.; Dömling, A.; Orru, R.V.A.; Wessjohann, L.A. “Rapid Combinatorial Access to Macrocyclic Ansapeptoids and Ansapeptides with Natural-Product-Like Core Structures” Synthesis-Stuttgart 2006, 23, 3997-4004.
Poot, A.J.; Ruijter, E.; Nuijens, T.; Dirksen, E.H.C.; Heck, A.J.R.; Slijper, M.; Rijkers, D.T.S.; Liskamp, R.M.J. “Selective Enrichment of Ser-/Thr-phosphorylated Peptides in the Presence of Ser-/Thr-glycosylated Peptides” Proteomics 2006, 6, 6394-6399.
Paravidino, M.; Bon, R.S.; Scheffelaar, R.; Vugts, D.J.; Znabet, A.; Schmitz, R.F.; de Kanter, F.J.J.; Lutz, M.; Spek, A.L.; Groen, M.B.; Orru, R.V.A. “Diastereoselective Multicomponent Synthesis of Dihydropyridones with an Isocyanide Functionality” Org. Lett. 2006, 8, 5369-5372.
Vugts, D.J.; Koningstein, M.M.; Schmitz, R.F.; de Kanter, F.J.J.; Groen, M.B.; Orru, R.V.A. “Multicomponent Synthesis of Dihydropyrimidines and Thiazines” Chem. Eur. J. 12, 7178-7189.
Orru, R.V.A. “MCRs and Related Chemistry” QSAR Comb. Sci. 2006, 25, 421-421.
Kreye, O.; Westermann, B.; Rivera, D.G.; Johnson, D.V.; Orru, R.V.A.; Wessjohann, L.A. “Dye-modified and Photoswitchable Macrocycles by Multiple Multicomponent Macrocyclizations Including Bifunctional Building Blocks (MiBs)” QSAR Comb. Sci. 2006, 25, 461-464.
Acke, D.R.J.; Orru, R.V.A.; Stevens, C.V. “Continuous Synthesis of Tri- and Tetrasubstituted Imidazoles via a Multicomponent Reaction under Microreactor Conditions” QSAR Comb. Sci. 2006, 25, 474-483.
Glasnov, T.N.; Vugts, D.J.; Koningstein, M.M.; Desai, B.; Fabian, W.M.F.; Orru, R.V.A.; Kappe, C.O. “Microwave-Assisted Dimroth Rearrangement of Thiazines to Dihydropyrimidinethiones: Synthetic and Mechanistic Aspects” QSAR Comb. Sci. 2006, 25, 509-518.
Vugts, D.J.; Veum, L.; al-Mafraji, K.; Lemmens, R.; Schmitz, R.F.; de Kanter, F.J.J.; Groen, M.B.; Hanefeld, U.; Orru, R.V.A. “A Mild Chemo-Enzymatic Oxidation-Hydrocyanation Protocol” Eur. J. Org. Chem. 2006, 7, 1672-1677.
Gelens, E.; De Kanter, F.J.J.; Schmitz, R.F.; Sliedregt, L.A.J.M.; Van Steen, B.J.; Kruse, C.G.; Leurs, R.; Groen, M.B.; Orru, R.V.A. “Efficient Library Synthesis of Imidazoles Using a Multicomponent Reaction and Microwave Irradiation” Mol. Divers. 2006, 10, 17-22.
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2005
Gelens, E.; Smeets, L.; Sliedregt, L.A.J.M.; van Steen, B.J.; Kruse, C.G.; Leurs, R.; Orru, R.V.A. “An Atom Efficient and Solvent-Free Synthesis of Structurally Diverse Amides Using Microwaves” Tet. Lett. 2005, 46, 3751-3754.
Bon, R.S.; van Vliet, B.; Sprenkels, N.E.; Schmitz, R.F.; de Kanter, F.J.J.; Stevens, C.V.; Swart, M.; Bickelhaupt, F.M.; Groen, M.B.; Orru, R.V.A. “Multicomponent Synthesis of 2-Imidazolines” J. Org. Chem. 2005, 70, 3542-3553.
Ruijter, E.; van der Veken, P.; Dirksen, E.H.C.; Elgersma, R.C.; Heck, A.J.R; Rijkers, D.T.S.; Slijper, M.; Liskamp, R.M.J. “Development of a Novel Chemical Probe for the Selective Enrichment of Phosphorylated Serine- and Threonine-Containing Peptides” ChemBioChem 2005, 2271-2280.
Wessjohann, L.A.; Ruijter, E.; Garcia-Rivera, D.; Brandt, W. “What Can a Chemist Learn from Nature’s Macrocycles? – A Brief, Conceptual View” Mol. Divers. 2005, 9, 171-186.
Wessjohann, L.A.; Ruijter, E. “Macrocycles Rapidly Produced by Multiple Multi-Component Reactions Including Bifunctional Building Blocks (MiBs)” Mol. Divers. 2005, 9, 159-169.
Wessjohann, L.A.; Ruijter, E. “Strategies for Total and Diversity-Oriented Synthesis of Natural Product(-Like) Macrocycles” Topics in Current Chemistry, Vol. 243 (2005): Natural Product Synthesis I: Targets, Methods, Concepts (Ed: J. Mulzer), 137-184.
Ruijter, E.; Schültingkemper, H.; Wessjohann, L.A. “Highly Substituted Tetrahydropyrones from Hetero-Diels-Alder Reactions of 2-Alkenals with Stereochemical Induction from Chiral Dienes” J. Org. Chem. 2005, 70, 2820-2823.
