Zhu, M.; Ruijter, E.; Wessjohann, L.A. “A New Scavenger Resin for the Reversible Linking and Monoprotection of Functionalized Aromatic Aldehydes.Org Lett. 2004, 6, 3921-3924.

Org Lett Ruijter

Scheid, G.; Ruijter, E.; Konarzycka-Bessler, M.; Bornscheuer, U.T.; Wessjohann, L.A. “Synthesis and Resolution of a Key Building Block for Epothilones: a Comparison of Asymmetric Synthesis, Chemical and Enzymatic Resolution.Tetrahedron: Asymm. 2004, 15, 2861-2869.

Tet Asym Ruijter

Scheid, G.; Kuit, W.; Ruijter, E.; Orru, R.V.A.; Henke, E.; Bornscheuer, U.; Wessjohann, L.A. “A New Route to Protected Acyloins and Their Enzymatic Resolution with Lipases.Eur. J. Org. Chem. 2004, 1063-1074.



Vugts, D.J.; Jansen, H.; Schmitz, R.F.; de Kanter, F.J.J.; Orru, R.V.A. “A Novel Four-component Reaction for the Synthesis of Functionalised Dihydropyrimidines” Chem. Comm. 2003, 20, 2594-2595.

Chem Comm Vugts

Bon, R.S.; Hong, C.G.; Bouma, M.J.; Schmitz, R.F.; de Kanter, F.J.J.; Lutz, M.; Spek, A.L.; Orru, R.V.A. “Novel Multicomponent Reaction for the Combinatorial Synthesis of 2-Imidazolines” Org. Lett. 2003, 5, 3759-3762.

Org Lett Bon

Orru, R.V.A.; de Greef, M. “Recent Advances in Solution-phase Multicomponent Methodology for the Synthesis of Heterocyclic Compounds” Synthesis Stuttgart 2003, 10, 1471-1499.

Orru, R.V.A.; Groenendaal, B.; van Heyst, J.; Hunting, M.; Wesseling, C.; Schmitz, R.F.; Mayer, S.F.; Faber, K. “Biomimetic Approach to the Stereoselective Synthesis of Acetogenins” Pure Appl. Chem. 2003, 75, 259-264.



Mayer, S.F.; Steinreiber, A.; Orru, R.V.A.; Faber, K. “Chemoenzymatic Asymmetric Total Syntheses of Antitumor Agents (3R,9R,10R)- and (3S,9R,10R)-panaxytriol and (R)- and (S)-Falcarinol from Panax Ginseng Using an Enantioconvergent Enzyme-triggered Cascade Reaction” J. Org. Chem. 2002, 67, 9115-9121.

JOC Mayer

Schrekker, H.S.; de Bolster, M.W.G.; Orru, R.V.A.; Wessjohann, L.A. “In Situ Formation of Allyl Ketones via Hiyama-Nozaki Reactions Followed by a Chromium-Mediated Oppenauer Oxidation” J. Org. Chem. 2002, 67, 1975-1981.

JOC Schrekker



Mayer, S.F.; Steinreiber, A.; Orru, R.V.A.; Faber, K. “Enzyme-triggered Enantioconvergent Transformation of Haloalkyl Epoxides” Eur. J. Org. Chem. 2001, 23, 4537-4542.

Mayer, S.F.; Steinreiber, A.; Orru, R.V.A.; Faber, K. “An Enzyme-triggered Enantio-convergent Cascade-Reaction” Tetrahedron: Asymmetry 2001, 12, 41-43.

Steinreiber, A.; Hellstrom, H.; Mayer, S.F.; Orru, R.V.A.; Faber, K. “Chemo-enzymatic Enantioconvergent Synthesis of C-4-building Blocks Containing a Fully Substituted Chiral Carbon Center Using Bacterial Epoxide Hydrolases” Synlett 2001, 1, 111-113.



Steinreiber, A.; Osprian, I.; Mayer, S.F.; Orru, R.V.A.; Faber, K. “Enantioselective Hydrolysis of Functionalized 2,2-Disubstituted Oxiranes with Bacterial Epoxide Hydrolases” Eur. J. Org. Chem. 2000, 22, 3703-3711.



van der Werf, M.J.; Orru, R.V.A.; Overkamp, K.M.; Swarts, H.J.; Osprian, I.; Steinreiber, A.; de Bont, J.A.M.; Faber, K. “Substrate Specificity and Stereospecificity of Limonene-1,2-Epoxide Hydrolase from Rhodococcus Erythropolis DCL14; an Enzyme Showing Sequential and Enantioconvergent Substrate Conversion” Appl. Microbiol. Biotechnol. 1999, 52, 380-385.

Osprian, I.; Jarret, C.; Strauss, U.; Kroutil, W.; Orru, R.V.A.; Felfer, U.; Willetts, A.J.; Faber, K. “Large-scale Preparation of a Nitrile-Hydrolysing Biocatalyst: Rhodococcus R 312 (CBS 717.73)” J. Mol. Catal. B: Enzym. 1999, 6, 555-560.

Orru, R.V.A.; Faber, K. “Stereoselectivities of Microbial Epoxide Hydrolases” Curr. Opin. Chem. Biol. 1999, 3, 16-21.

Orru, R.V.A.; Archelas, A.; Furstoss, R.; Faber, K. “Epoxide Hydrolases and Their Synthetic Applications” Adv. Biochem. Eng./Biotechnol. 1999, 63, 145-167.



Orru, R.V.A.; Osprian, I.; Kroutil, W.; Faber, K. “An Efficient Large-scale Synthesis of (R)-(-)-Mevalonolactone Using Simple Biological and Chemical Catalysts” Synthesis-Stuttgart 1998, 9, 1259-1263.

Kroutil, W.; Orru, R.V.A.; Faber, K. “Stabilization of Nocardia EH1 Epoxide Hydrolase by Immobilization” Biotechnol. Lett. 1998, 20, 373-377.

Orru, R.V.A.; Mayer, S.F.; Kroutil, W.; Faber, K. “Chemoenzymatic Deracemization of (+/-)-2,2-Disubstituted Oxiranes” Tetrahedron 1998, 54, 859-874.



Orru, R.V.A.; Kroutil, W.; Faber, K. “Deracemization of (+/-)-2,2-Disubstituted Epoxides via Enantioconvergent Chemoenzymatic Hydrolysis using Nocardia EH1 Epoxide Hydrolase and Sulfuric Acid” Tetrahedron Lett. 1997, 38, 1753-1754.



Piet, D.P.; Orru, R.V.A.; Jenniskens, L.H.D.; van de Haar, C.; van Beek, T.A.; Franssen, M.C.R.; Wijnberg, J.B.P.A.; de Groot, A. “Synthesis of (1 alpha,7 alpha,8 beta)-(+/-)-8-methyl-2-methylenebicyclo[5.3.0]dec-5-en-8-ol. Structure Revision of Natural Dictamnol” Chem. Pharm. Bull. 1996, 44, 1400-1403.



Bastiaansen, P.M.F.M.; Orru, R.V.A.; Wijnberg, J.B.P.A.; De Groot, A. “Long-range Effects of Through-bond Orbital Interactions on the Desilylation rate of Silyl Ethers” J. Org. Chem. 1995, 60, 6154-6158.

Orru, R.V.A.; Wijnberg, J.B.P.A.; De Groot, A. “Substituent Effects on Through-Bond Orbital Interaction-induced Heterolysis of some Perhydronaphtalene-1,4-diol Monosulfonate Esters” J. Org. Chem. 1995, 60, 4233-4239.



De Groot, A.; Jansen, B.J.M.; Verstegen Haaksma, A.A.; Swarts, H.J.; Orru, R.V.A.; Stork, G.A.; Wijnberg, J.B.P.A. “Recent Developments in the Synthesis of Drimane and Lactarane Sesquiterpenes” Pure Appl. Chem. 1994, 66, 2053-2056.

Orru, R.V.A.; Wijnberg, J.B.P.A.; Bouwman, C.T.; De Groot, A. “Rearrangement vs Homofragmentation – Chemical Consequences of Different Sigma-Relays on the Heterolysis of Sulfonate Esters Induced by Through-Bond Interactions” J. Org. Chem. 1994, 59, 374-382.



Orru, R.V.A.; Wijnberg, J.B.P.A.; Jennikens, L.H.D.; De Groot, A. “Intramolecular Alkoxide Induced Heterolysis of Perhydronaphtalene-1,4-diol Monosulfonate Esters through Orbital Interactions over 3 C-C Single Bonds” J. Org. Chem. 1993, 58, 1199-1206.



Gijsen, H.J.M.; Kanai, K.; Stork, G.A.; Wijnberg, J.B.P.A.; Orru, R.V.A.; Seelen, C.G.J.M.; van der Kerk, S.M.; De Groot, A. “The Conversion of Natural (+)-Aromadendrene into Chiral Synthons.1.” Tetrahedron 1990, 46, 7236-7246.