Martha, C.T.; Heemskerk, A.; Hoogendoorn, J.C.; Elders, N.; Niessen, W.M.A.; Orru, R.V.A.; Irth, H. “High-Throughput Reaction Optimisation and Activity Screening of Ferrocene-Based Lewis Acid-Catalyst Complexes by Using Continuous-Flow Reaction Detection Mass SpectrometryChem. Eur J. 2009, 15, 7368-7375.Chem Eur J Martha

Elders, N.; van der Born, D.; Hendrickx, L. J. D. ; Timmer, B. J. J.; Krause, A.; Janssen, E.; de Kanter, F. J. J.; Ruijter, E.; Orru, R. V. A. “The Efficient One-Pot Reaction of up to Eight Components by the Union of Multicomponent ReactionsAngew. Chem. Int. Ed. 2009, 48, 5856-5859.

Angewandte Niels

Elders, N.; Ruijter, E.; de Kanter, F. J. J.; Janssen, E.; Lutz, M.; Spek, A. L.; Orru, R. V. A. “A Multicomponent Reaction Towards N-(Cyanomethyl)amidesChem. Eur. J. 2009, 15, 6096-6099.

Chem Eur J Niels

Scheffelaar, R.; Klein Nijenhuis, R.A.; Paravidino, M.; Lutz, M.; Spek, A.L.; Ehlers, A.W.; de Kanter, F.J.J.; Groen, M.B. Orru, R.V.A.; Ruijter, E. “Synthesis of Conformationally Constrained Peptidomimetics using Multicomponent ReactionsJ. Org. Chem. 2009, 74, 660-668.

JOC Scheffelaar2

Scheffelaar, R.; Paravidino, M.; Muilwijk, D.; Lutz, M.; Spek, A.L.; de Kanter, F.J.J.; Orru, R.V.A.; Ruijter, E. “A Novel Three-Component Reaction toward DihydrooxazolopyridinesOrg. Lett. 2009,11, 125-128.

Org Lett Scheffelaar

Gubbens, J.; Ruijter, E.; de Fays, L.E.V.; Damen, J.M.A.; de Kruijff, B.; Slijper, M.; Rijkers, D.T.S.; Liskamp, R.M.J.; de Kroon, A.I.P.M. “Photocrosslinking and click chemistry enable the specific detection of proteins interacting with phospholipids at the membrane interfaceChem. Biol. 2009, 16, 3-14.



Groenendaal, B.; Ruijter, E.; Orru, R.V.A. “1-Azadienes in cycloaddition and multicomponent reactions towards N-heterocyclesChem. Commun. 2008, 5474-5489 (feature article).

Chem Comm Groenendaal

Martha, C.T.; Elders, N.; Krabbe, J.G.; Kool, J.; Niessen, W.M.A.; Orru, R.V.A.; Irth, H. “Online screening of homogeneous catalyst performance using reaction detection mass spectrometry” Anal. Chem. 2008, 80, 7121-7127.

Anal Chem Martha

Groenendaal, B.; Ruijter, E.; de Kanter, F.J.J.; Lutz, M.; Spek, A.L.; Orru, R.V.A. “Generation of molecular diversity using a complexity-generating MCR-platform towards triazinane dionesOrg. Biomol. Chem. 2008, 6, 3158-3165.

Org Biomol Chem Groenendaal

Elders, N.; Ruijter, E.; de Kanter, F.J.J.; Groen, M.B.; Orru, R.V.A. “Selective Formation of 2-Imidazolines and 2-Substituted Oxazoles by Using a Three-Component ReactionChem. Eur. J. 2008, 14, 4961-4973.

Chem Eur J Niels 2

Vugts, D.J.; Aktas, H.; Al-Mafraji, K.; de Kanter, F.J.J.; Ruijter, E.; Groen, M.B.; Orru, R.V.A. “Synthesis of 3′-Deoxyribolactones using a Hydrolysis-Induced Lactonization Cascade Reaction of Epoxy CyanohydrinsEur. J. Org. Chem. 2008, 1336-1339.

Eur J Org Chem Vugts

Groenendaal, B.; Vugts, D.J.; Schmitz, R.F.; de Kanter, F.J.J.; Ruijter, E.; Groen, M.B.; Orru, R.V.A. “A Multicomponent Synthesis of Triazinane DionesJ. Org. Chem. 2008, 73, 719-722.

JOC Groenendaal

Bon, R.S.; Sprenkels, N.E.; Koningstein, M.M.; Schmitz, R.F.; de Kanter, F.J.J.; Dömling, A.; Groen, M.B.; Orru, R.V.A. “Efficient C2 functionalisation of 2H-2-imidazolines” Org. Biomol. Chem. 2008, 6, 130-137.

Org Biomol Chem Bon



Paravidino, M.; Scheffelaar, R.; Schmitz, R.F.; de Kanter, F.J.J.; Groen, M.B.; Ruijter, E.; Orru, R.V.A. “A Flexible Six-Component Reaction to Access Constrained Depsipeptides Based on a Dihydropyridinone Core.J. Org. Chem. 2007, 72, 10239-10242.

JOC Paravidino

Elders, N.; Schmitz, R.F.; de Kanter, F.J.J.; Ruijter, E.; Groen, M.B.; Orru, R.V.A. “A Resource-Efficient and Highly Flexible Procedure for a Three-Component Synthesis of 2-ImidazolinesJ. Org. Chem. 2007, 72, 6135-6142.

JOC Niels

Bon, R.S.; de Kanter, F.J.J.; Lutz, M.; Spek, A.L.; Jahnke, M.C.; Hahn, F.E.; Groen, M.B.; Orru, R.V.A. “Multicomponent synthesis of N-heterocyclic carbene complexes” Organometallics 2007, 26, 3639-3650.

Organometallics Bon



de Greef, M.; Abeln, S.; Belkasmi, K.; Dömling, A.; Orru, R.V.A.; Wessjohann, L.A. “Rapid combinatorial access to macrocyclic ansapeptoids and ansapeptides with natural-product-like core structures” Synthesis-Stuttgart 2006, 23, 3997-4004.

Poot, A.J.; Ruijter, E.; Nuijens, T.; Dirksen, E.H.C.; Heck, A.J.R.; Slijper, M.; Rijkers, D.T.S.; Liskamp, R.M.J. “Selective enrichment of Ser-/Thr-phosphorylated peptides in the presence of Ser-/Thr-glycosylated peptidesProteomics 2006, 6, 6394-6399.

Paravidino, M.; Bon, R.S.; Scheffelaar, R.; Vugts, D.J.; Znabet, A.; Schmitz, R.F.; de Kanter, F.J.J.; Lutz, M.; Spek, A.L.; Groen, M.B.; Orru, R.V.A. “Diastereoselective multicomponent synthesis of dihydropyridones with an isocyanide functionality” Org. Lett. 2006, 8, 5369-5372.

Org Lett Paravidino

Vugts, D.J.; Koningstein, M.M.; Schmitz, R.F.; de Kanter, F.J.J.; Groen, M.B.; Orru, R.V.A. “Multicomponent synthesis of dihydropyrimidines and thiazinesChem. Eur. J.  12, 7178-7189.

Chem Eur J Vugts

Orru, R.V.A. “MCRs and related chemistry” QSAR Comb. Sci. 2006, 25, 421-421.

Kreye, O.; Westermann, B.; Rivera, D.G.; Johnson, D.V.; Orru, R.V.A.; Wessjohann, L.A. “Dye-modified and photoswitchable macrocycles by multiple multicomponent macrocyclizations including bifunctional building blocks (MiBs)” QSAR Comb. Sci. 2006, 25, 461-464.

Acke, D.R.J.; Orru, R.V.A.; Stevens, C.V. “Continuous synthesis of tri- and tetrasubstituted imidazoles via a multicomponent reaction under microreactor conditions” QSAR Comb. Sci. 2006, 25, 474-483.

Glasnov, T.N.; Vugts, D.J.; Koningstein, M.M.; Desai, B.; Fabian, W.M.F.; Orru, R.V.A.; Kappe, C.O. “Microwave-assisted Dimroth rearrangement of thiazines to dihydropyrimidinethiones: Synthetic and mechanistic aspects” QSAR Comb. Sci. 2006, 25, 509-518.

Vugts, D.J.; Veum, L.; al-Mafraji, K.; Lemmens, R.; Schmitz, R.F.; de Kanter, F.J.J.; Groen, M.B.; Hanefeld, U.; Orru, R.V.A. “A mild chemo-enzymatic oxidation-hydrocyanation protocol” Eur. J. Org. Chem. 2006, 7, 1672-1677.

Eur J Org Chem Vugts2

Gelens, E.; De Kanter, F.J.J.; Schmitz, R.F.; Sliedregt, L.A.J.M.; Van Steen, B.J.; Kruse, C.G.; Leurs, R.; Groen, M.B.; Orru, R.V.A. “Efficient library synthesis of imidazoles using a multicomponent reaction and microwave irradiation” Mol. Divers. 2006, 10, 17-22.



Gelens, E.; Smeets, L.; Sliedregt, L.A.J.M.; van Steen, B.J.; Kruse, C.G.; Leurs, R.; Orru, R.V.A. “An atom efficient and solvent-free synthesis of structurally diverse amides using microwaves” Tet. Lett.  2005, 46, 3751-3754.

Tet Lett Gelens

Bon, R.S.; van Vliet, B.; Sprenkels, N.E.; Schmitz, R.F.; de Kanter, F.J.J.; Stevens, C.V.; Swart, M.; Bickelhaupt, F.M.; Groen, M.B.; Orru, R.V.A. “Multicomponent synthesis of 2-imidazolines” J. Org. Chem. 2005, 70, 3542-3553.


Ruijter, E.; van der Veken, P.; Dirksen, E.H.C.; Elgersma, R.C.; Heck, A.J.R; Rijkers, D.T.S.; Slijper, M.; Liskamp, R.M.J. “Development of a novel chemical probe for the selective enrichment of phosphorylated serine- and threonine-containing peptidesChemBioChem 2005, 2271-2280.

ChemBioChem Ruijter

Wessjohann, L.A.; Ruijter, E.; Garcia-Rivera, D.; Brandt, W. “What can a chemist learn from nature’s macrocycles? – A brief, conceptual viewMol. Divers. 2005, 9, 171-186.

Wessjohann, L.A.; Ruijter, E. “Macrocycles rapidly produced by multiple multi-component reactions including bifunctional building blocks (MiBs)Mol. Divers. 2005, 9, 159-169.

Wessjohann, L.A.; Ruijter, E. “Strategies for Total and Diversity-Oriented Synthesis of Natural Product(-Like) Macrocycles” Topics in Current Chemistry, Vol. 243 (2005): Natural Product Synthesis I: Targets, Methods, Concepts (Ed: J. Mulzer), 137-184.

Top Ruijter

Ruijter, E.; Schültingkemper, H.; Wessjohann, L.A. “Highly substituted tetrahydropyrones from hetero-Diels-Alder reactions of 2-alkenals with stereochemical induction from chiral dienesJ. Org. Chem. 2005, 70, 2820-2823.

JOC Ruijter